The 970 pixel grid.
I’ve been using the 970 pixel grid for a little while now, and I agree with those who argue it has many advantages over the traditional 960 pixel grid. For more information, read this article. To download a layered Photoshop file with grid and measurements that I developed, click here.
The wireframe tool (HotGloo) I’ve been using for about 9 months now also has the 960 grid as a background guide, but you can adjust the gutter and column widths which is pretty nice. I do agree that the 20px gutter is way too wide. It leaves content areas floating in space.